Viral therapy of human cancers



Publisher: Marcel Dekker in Boca Raton, Fla

Written in English
Published: Pages: 829 Downloads: 765
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Subjects:

  • Viruses -- Therapeutic use,
  • Cancer -- Treatment

Edition Notes

Includes bibliographical references and index.

Statementedited by Joseph G. Sinkovics, Joseph C. Horvath.
ContributionsSinkovics, Joseph G., 1924-, Horvath, Joseph C.
Classifications
LC ClassificationsRC271.V567 V55 2005
The Physical Object
Paginationxiii, 829 p. :
Number of Pages829
ID Numbers
Open LibraryOL21187988M
ISBN 100824759133
LC Control Number2005040475
OCLC/WorldCa58919655

  Dr. Andrejs Liepins/SPL. Killer T cells (orange) are recruited to attack malignant cells (mauve) in the viral-based cancer therapy T-VEC.   Viral Therapy in Treating Patients With Metastatic Melanoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Targeted viral therapy destroys breast cancer stem cells in preclinical experiments The researchers found that infection of human breast cancer cells with the adenovirus decreased the.   Scientists have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from .

  There are government licensed viral gene therapy products currently in use for head and neck cancer, utilised in conjunction with established treatment modalities. The viruses target tumour-associated genes, with the first licensed virus replacing p53 gene function, which is frequently lost in .   Gene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease. The gene therapy is one of promising therapies for a number of diseases such as inherited disorders, viral infection and cancers. The useful results of gene delivery systems depend open the adjustable.

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Viral Therapy of Human Cancers 1st Edition by Joseph G. Sinkovics (Editor), Joseph Horvath (Editor) ISBN ISBN Why is ISBN important.

ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. The digit and digit formats both work. Viral Therapy of Human Cancers (Basic and Clinical Oncology) 1st Edition by Joseph G.

Sinkovics (Editor), Joseph Horvath (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.

Format: Hardcover. Featuring contributions from nearly 30 leading authorities, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and eCited by: Book Description.

Featuring contributions from nearly 30 leading Viral therapy of human cancers book, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and experimental studies.

ISBN: OCLC Number: Description: xiii, pages: illustrations ; 24 cm: Contents: Progressive development of viral therapy of human cancers: a personal narrative account --New biological therapeutics: competitors or collaborators of viral therapy for human cancers --Measles virus: improving natural oncolytic properties by genetic engineering --Antitumor.

This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they Price: $   This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer.

Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer.

Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they.

This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well.

Book Review Viral Therapy of Human Cancers Eds. Joseph G. Sinkovics, Joseph C. Horvath. pages, references. Marcel Dekker, New York, Folia Biologica (Praha) 51, () so-called “natural hybridomas”, i.e. fusion cells that permanently produce antibodies. You are buying ONE brand new BOOK Viral Therapy of Human Cancers.

Year first published: Approximate dimensions: 9 inches x 6 inches. Author: Joseph G. Sinkovics. Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in.

In this manuscript, we report a survey of viral sequences present in TCGA data representing 22 distinct types of human cancers.

This is the first study to combine DNA (WGS and WXS) and RNA sequencing data sets to search for viral sequences present in human cancers and to deduce their effects of cellular gene expression. Results 1. Melanoma Res. Aug;13(4) Virus therapy of human cancers.

Sinkovics JG, Horvath JC. PMID: [PubMed - indexed for MEDLINE]. Oncolytic viroimmunotherapy is an exciting modality that can offer lasting anti-tumor immunity for aggressive malignancies like colon cancer. The impact of oncolytic viruses may be extended by combining them with agents to prime a tumor for viral susceptibility.

This study investigates vitamin D analogue as an adjunct to oncolytic viral therapy for colon cancer. There is currently one oncolytic virus therapy approved by the FDA for the treatment of cancer: T-VEC (Imlygic®): a modified herpes simplex virus (HSV) that infects tumor cells and promotes their destruction; approved for subsets of patients with melanoma Side Effects.

Side effects may vary according to the type of oncolytic virus—and what exactly it targets—and may also be influenced by. Purpose: Pancreatic cancer has a poor prognosis and few effective therapies are available. The oncolytic effect of reovirus has been observed in cancer cells with an activated Ras signaling pathway, and pancreatic cancer may be a candidate target for reovirus because K-ras mutation is frequently found in pancreatic cancer.

Experimental Design: In this study, we examined the feasibility of. Book; Published: December ; Viral therapy of human cancer. Viral therapy of human cancer. Pathol. Oncol. Res. 11, () doi Newcastle Disease Virus; Oncolytic Virus; Pathology Oncology Research; Viral Therapy; Buy or subscribe.

Advertisement. Over 10 million scientific documents at your fingertips. Switch Edition. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.

Viral therapy for cancer, also called oncolytic viral therapy or viral immunotherapy, makes use of viruses to treat cancer. Typically we think of viruses as tiny bugs that infect our body and cause diseases like the flu, but in this case, viruses are modified to infect and kill cancer.

Gene therapy alters the genetic instructions within an individual’s cells. A gene is a sequence of DNA — pictured above. A variety of efforts are underway to apply gene therapy to cancer treatment.

Most are in early, exploratory stages, where they’re. Virotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral branches utilize three different types of treatment methods: gene overexpression, gene knockout, and suicide gene delivery.

Worldwide, cancer viruses are estimated to cause 15 to 20 percent of all cancers in humans. Most viral infections, however, do not lead to tumor formation as several factors influence the progression from viral infection to cancer development.

In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.

Virology is the study of viruses – submicroscopic, parasitic particles of genetic material contained in a protein coat – and virus-like agents. It focuses on the following aspects of viruses: their structure, classification and evolution, their ways to infect and exploit host cells for reproduction, their interaction with host organism physiology and immunity, the diseases they cause, the.

Oncolytic viral therapy is a new promising strategy against cancer. Oncolytic viruses (OVs) can replicate in cancer cells but not in normal cells, leading to lysis of the tumor mass. Beside this primary effect, OVs can also stimulate the immune system.

Tumors are an immuno-suppressive environment in which the immune system is silenced in order to avoid the immune response against cancer.

EBV illustrates cryptic viral causation of cancers that are characterized by low and high viral loads. In the cancers for which EBV was accepted decades ago—endemic Burkitt's lymphoma, nasopharyngeal carcinoma, post-transplant lymphoma—the ratio of viral genome to.

Expert opinion: Metastatic breast cancer is a perfect candidate for gene therapy approaches due to the presence of several tumor antigens and the aberrant expression of many molecular pathways.

Oncolytic vectors are able to attack tumor cells while sparing normal cells and their activity is often enhanced by the administration of chemotherapy. Merck's role in the VCP was "to conduct investigations designed to develop vaccines or other agents effective for the prophylaxis and therapy for human neoplasia (cancer) of suspected viral etiology" (;).

Great interest was taken in developing anti-herpes virus vaccines. Michelle Qaqundah, ND, FABNO. It has been just over a century since Ellerman and Bang first demonstrated that transmissible viruses can cause cancer when they linked what later proved to be an avian retrovirus to leukemia.1 Since that time the idea that cancer is of viral origin has come in and out of favor.

There have been periods when it was believed that all cancers were caused by viral. In lung cancer, miRa has been reported to be a potential targeted therapy for lung cancer. MicroRNA-loaded minicells (miRbased mimic miRNA) are designed to counteract the loss of the miR and miR family and are used in clinic trials for small-cell lung cancer and mesothelioma [ .Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy.

It covers the history and current and future applications of gene transfer in cancer, and provides.Gene therapies are gaining momentum as promising early successes in clinical studies accumulate and examples of regulatory approval for licensing increase. Investigators are advancing with cautious optimism that effective, durable, and safe therapies will provide benefit to patients—not only those with single-gene disorders but those with complex acquired diseases as well.

While the.